Profluent Bio uses frontier AI models to design novel proteins—such as genome editors, antibodies and enzymes—for therapeutics, agriculture and biomanufacturing applications.
<div class="content-intro"><p>Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.</p></div><p>We’re looking for a product-minded engineering manager to lead Profluent’s Lab Informatics Platform team. This role combines engineering management, technical leadership, and product ownership for the systems scientists use to design experiments, track samples, capture assay data, integrate with Benchling and lab automation, and make experimental data usable for analysis and machine learning.<br><br>The ideal candidate is an experienced people manager with a strong technical foundation and sound product judgment. You’ll manage and mentor a small team while staying close to architecture, data modeling, database design, and technical decision-making. You’ll work closely with wet-lab scientists, automation engineers, data scientists, and ML experts to understand workflows, identify pain points, define requirements, prioritize tradeoffs, and lead the delivery of practical scientist-facing tools that make complex experimental workflows scalable, traceable, and actionable.</p> <p><strong>Responsibilities </strong></p> <ul> <li>Lead, mentor, and grow a software engineering team focused on lab informatics, scientific data infrastructure, and scientist-facing applications</li> <li>Own and communicate the roadmap for Profluent’s lab informatics platform, balancing scientific impact, user needs, engineering effort, usability, scalability, and long-term data strategy</li> <li>Architect and guide delivery of systems that support sample tracking, assay data capture, Benchling integration, lab automation, experimental metadata, and analysis workflows</li> <li>Design robust data models for protein engineering and gene editing experiments, including constructs, samples, reagents, cell systems, assay results, metadata, and experimental lineage across mammalian and bacterial workflows</li> <li>Partner closely with scientists, automation engineers, data scientists, and ML researchers to understand workflows, identify pain points, define requirements, prioritize tradeoffs, and translate complex laboratory needs into scalable software solutions that accelerate Profluent’s design-build-test-learn cycle</li> <li>Establish strong engineering and product practices across architecture, technical design, code review, testing, CI/CD, documentation, stakeholder communication, feedback loops, success metrics, adoption, and agile delivery</li> </ul> <p><strong>Qualifications </strong></p> <ul> <li>7+ years of software engineering experience, including at least 2 years managing or leading engineers</li> <li>BS, MS, or PhD in Computer Science, Bioengineering, Computational Biology, or a related field</li> <li>Strong technical leadership skills, with a track record of architecting and delivering production-quality software systems through teams</li> <li>Proficiency with Python, backend development, databases, APIs, and modern software engineering workflows, with the ability to guide technical design and implementation</li> <li>Experience building or leading teams that build scientific data platforms, LIMS integrations, research software, or scientist-facing applications, including data modeling and database design for complex scientific or experimental workflows</li> <li>Demonstrated ability to work closely with scientists and technical stakeholders to translate ambiguous laboratory workflows into reliable software systems, define requirements, prioritize tradeoffs, and drive adoption of internal tools</li> </ul> <p><strong>Preferences </strong></p> <ul> <li>Experience with Benchling, lab automation, instrument data ingestion, sample tracking, or high-throughput experimental data</li> <li>Experience with data generated from mammalian or bacterial cell systems, gene editing, protein engineering, or related biological workflows</li> <li>Frontend web development experience and interest in building intuitive scientist-facing user interfaces</li> </ul> <p><strong>What We Offer</strong></p> <ul> <li class="whitespace-normal break-words">High-growth opportunity with meaningful impact on the future of protein design</li> <li class="whitespace-normal break-words">Competitive compensation package with equity participation</li> <li class="whitespace-normal break-words">401(k) with a strong employer match</li> <li class="whitespace-normal break-words">Comprehensive benefits including health/dental/vision insurance</li> <li class="whitespace-normal break-words">Generous PTO policy and commitment to work-life balance</li> <li class="whitespace-normal break-words">Professional development opportunities in a cutting-edge field at the intersection of AI and biology</li> </ul> <p>Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.</p> <p><strong>Work Authorization Requirement</strong></p> <p>Applicants must have ongoing work authorization in the United States that does not require employer sponsorship. Sponsorship will not be provided now or at any time in the future for this position.</p> <p><strong>Employment Eligibility Verification</strong></p> <p>Legal authorization to work in the United States is requ