Radical Numerics builds general biological intelligence and genome language models for biological design and biodefense.
ABOUT US Radical Numerics http://radicalnumerics.ai is an AI research lab building general biological intelligence. Our mission is to master the code of life, and our purpose is to reduce human suffering. Our team created Evo, and started the field of generative genomics. Our work was featured on the cover of Science https://www.science.org/doi/10.1126/science.ado9336, and presented by our CEO on the main stage of TED2025 https://www.youtube.com/watch?v=EnbfoFUFm2s. Evo was used to create the first AI gene therapy tool CRISPR-Cas9, and the first AI whole genome https://www.biorxiv.org/content/10.1101/2025.09.12.675911v1 from scratch. Evo 2 https://www.nature.com/articles/s41586-026-10176-5, featured in Nature, is the largest fully open source AI project across any domain. Radical Numerics is bringing the rigor of distributed systems, model architecture, and numerics research to the challenges of biology. We’ve redesigned the foundation model training stack to turn the world’s raw scientific data (e.g. biological sequences, experiments, and physical processes), into intelligible, generative models that can expand and accelerate what humanity can understand, design, and cure. The same generative breakthroughs that enable life-saving cures also lowers the barrier to creating engineered threats and AI-generated bioweapons. We believe these forces are inseparable. Radical Numerics was founded to develop both the power to design and the responsibility to defend. ABOUT THE ROLE As a Member of Technical Staff, Infrastructure & Training Systems at Radical Numerics, you will design and build the systems that make large-scale model training possible across research and deployment workflows. You will work on distributed training, performance optimization, reusable internal frameworks, and the tooling that helps researchers move quickly without sacrificing reliability. This role is ideal for someone who combines deep systems instincts with an interest in modern machine learning. You should care about how every layer of the stack affects research velocity: kernel performance, communication overhead, fault tolerance, observability, reproducibility, and the ergonomics of the training loop itself. We believe biological world models will require not only strong research ideas, but exceptional training and inference systems: infrastructure that makes large-scale experimentation efficient, reproducible, and robust enough to support rapid scientific iteration. This role is focused on building that foundation. WHAT YOU’LL DO - Design and scale distributed training systems. Build and optimize distributed training infrastructure for large-scale biological world models across large distributed compute systems, with a focus on performance, stability, and scalability. - Maximize throughput and hardware efficiency. Develop performance optimizations across the stack, including communication patterns, memory efficiency, custom kernels, compilation paths, and systems instrumentation, to ensure training compute is used effectively. - Build reusable training frameworks. Develop internal libraries, abstractions, and workflows that improve reproducibility, reliability, and scalability across new model architectures and training recipes. - Improve reliability under rapid iteration. Establish standards and mechanisms for robustness, maintainability, debugging, and safe deployment of fast-moving research infrastructure. That includes fault tolerance, checkpointing, monitoring, experiment hygiene, and incident analysis. - Collaborate across research and engineering. Partner closely with model researchers, training scientists, and data/infrastructure engineers to identify bottlenecks, unblock experiments, and design systems that support new scientific directions rather than constrain them. - Support new architectures and training paradigms. Adapt infrastructure to the needs of multimodal models, long-context training, and evolving model architectures, so the systems stack remains a research multiplier as model requirements change. WHAT WE’RE LOOKING FOR - Strong engineering track record in distributed systems, high-performance ML infrastructure, training systems, or closely related areas. - Proficiency in building performant, maintainable software in Python, PyTorch, Triton, CUDA, and C++. - Strong understanding of modern deep learning frameworks and their systems internals. - Ability to debug complex, multi-layered systems involving distributed training, memory/performance regressions, and reliability issues in large codebases. - Comfort working in a highly collaborative environment with researchers, engineers, and domain experts, with a bias toward initiative and execution. - Excellent written and verbal communication skills bridging technical and scientific domains. NICE TO HAVE - Experience with large-scale distributed training for frontier or foundation models. - Contributions to open-source ML systems or infrastructure such as PyTorch, Torchtitan or Megatron-LM. - Familiarity with ML runtimes, compilers, numerics, communication libraries, and custom kernel development. - Experience improving researcher productivity through infrastructure design, developer tooling, or workflow improvements. - Background in applied math, systems, computational biology, or related quantitative sciences. WHY RADICAL NUMERICS - Help build the computational foundation for multimodal biological world models aimed at rapid detection, response, and countermeasures across global health. - Work on systems problems at the frontier of distributed training, architecture, and numerics, in service of real biological applications. - Join a collaborative culture that values rigor, creativity, and cross-disciplinary partnership across AI labs, biotechs, hospital systems, and research institutes. - Competitive compensation, comprehensive benefits, and suppo