Profluent Bio uses frontier AI models to design novel proteins—such as genome editors, antibodies and enzymes—for therapeutics, agriculture and biomanufacturing applications.
<div class="content-intro"><p>Profluent is an AI-first protein design company. Founded in 2022, we develop deep generative models to design and validate novel, functional proteins to revolutionize biomedicine. Based in Emeryville, CA, we are backed by leading investors including Altimeter Capital, Bezos Expeditions, Spark Capital, Insight Partners, Air Street Capital, AIX Ventures, and Convergent Ventures, and have raised over $150M to date.</p></div><p>We're looking for a motivated and creative Machine Learning (ML) Scientist to drive research into reinforcement learning for biomolecular design. This position offers an opportunity to work at the forefront of generative modeling research across language processing, representation learning, and protein engineering. You should be a self-directed researcher who has the ability to rapidly prototype and evaluate new models and algorithms in the biomolecular domain.</p> <p>As an early employee, you will proactively shape the direction of our machine learning efforts and collaborate across diverse teams of computational and experimental scientists.</p> <p><strong>Responsibilities</strong></p> <ul> <li>Design and develop state-of-the-art online and offline reinforcement learning algorithms for protein design</li> <li>Collaborate across the machine learning and protein design teams to adapt and improve reinforcement learning techniques from other domains to protein design</li> <li>Architect, implement, and optimize core infrastructure to support the post-training of protein language models</li> <li>Curate relevant datasets and design tasks for rigorous evaluation of generative models</li> <li>Implement, analyze, and interpret multiple computational approaches and present results to colleagues in regular update meetings</li> <li>Work within a collaborative, fast-paced, interdisciplinary team across biology and machine learning to help shape the scientific and strategic vision of the company</li> </ul> <p><strong>Qualifications</strong></p> <ul> <li>PhD (or equivalent industry experience) in Computer Science, Machine Learning, Natural Language Processing, Applied Math, Computational Biology, Statistics, or a related field</li> <li>Experience with conceiving of, implementing, and evaluating novel machine learning and reinforcement learning techniques</li> <li>Publications at major machine learning conferences (NeurIPS, ICML, ICLR) or scientific journals (Nature, Science, Nature Biotech, Nature Methods, PNAS)</li> <li>Experience with modern deep learning frameworks such as Pytorch or Jax</li> </ul> <p><strong>Preferences</strong></p> <ul> <li>Familiarity with foundational biology of proteins and nucleic acids</li> <li>Experience developing machine learning models for proteins (language models, structure prediction, design)</li> <li>Experience with cloud compute platforms (GCP, AWS, Azure, OCI)</li> <li>Previous experience in data extraction and curation from bioinformatics data sources</li> <li>Familiarity with wet lab experimental assays and associated limitations</li> </ul> <p><strong>What We Offer</strong></p> <ul> <li class="whitespace-normal break-words">High-growth opportunity with meaningful impact on the future of protein design</li> <li class="whitespace-normal break-words">Competitive compensation package with equity participation</li> <li class="whitespace-normal break-words">401(k) with a strong employer match</li> <li class="whitespace-normal break-words">Comprehensive benefits including health/dental/vision insurance</li> <li class="whitespace-normal break-words">Generous PTO policy and commitment to work-life balance</li> <li class="whitespace-normal break-words">Professional development opportunities in a cutting-edge field at the intersection of AI and biology</li> </ul> <p>Profluent Bio, Inc is an equal opportunity employer promoting diversity and inclusion in the workspace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law.</p> <p><strong>Employment Eligibility Verification</strong></p> <p>Legal authorization to work in the United States is required. In compliance with federal law, all persons hired must verify their identity and work eligibility and complete the required employment verification form upon hire.</p><div class="content-pay-transparency"><div class="pay-input"><div class="title">Hiring Salary Range</div><div class="pay-range"><span>$200,000</span><span class="divider">—</span><span>$330,000 USD</span></div></div></div>